Dust and sand storms are considered a usual atmospheric phenomena in many countries of the world, especially in arid and semi-arid regions. In this study, for statistical analysis of dust during the period of 2004-2018, the data of the present weather, the horizontal view and the wind speed and direction received from Iran Meteorological Organization, for the synoptic analysis was used the NCEP / NCAR reanalysis data and for path analysis of dust mass was used by NCAR GDAS data with 0.5 × 0.5 degree resolution. To investigate the variability of dust storm, the frequency of present weather code related to dust event at 15 synoptic stations was used hourly, daily, seasonal and annual. For investigate the dust trajectory in Isfahan province, used the HYSPLIT model with the backward trajectories' method at three altitudes (500, 1000 and 3000 meter above the ground) at four widespread dust storm cases. The results show that the pressure gradient between northern high pressure and southern low pressure is the main cause of northeast to east winds that passing through the main source of dust formation mostly in the Kavir desert and inland areas of the province caused the dust storm event.