Probabilistic hazard assessment concepts consider some uncertainties, including size, location, and the rate of earthquake recurrence. These uncertainties are quantified in PSHA. The study region is located in Khorasan Razavi, with longitude between 55.5 ̊ and 60 ̊ E, and latitude from 35 ̊ to 38 ̊ N. Complete earthquake catalogue was collected from different agencies. Faults were digitized throughout geology maps; then seismic sources were delineated according to faults directions. Due to the fact that most buildings in this region are between 2 and 8 stories, spectral acceleration was calculated for structural period between 0.2 and 0.8 second in with the center of Imam Reza shrine. Also, seismic hazard was assessed by OpenQuake software according to Campel-Bozorgnia (2014) attenuation relation and logic tree. Finally, seismic hazard map were plotted in different returning periods.