This study aims to investigate the interaction between the Indian Monsoon and Madden-Julian Oscillation as two inter seasonal tropical phenomena. To this end, the Indian Monsoon Index was identified using data from the University of Hawaii website, and the NCEP/NCAR reanalysis data with spatial resolution of 2.5 × 2.5 degrees were used to determine different phases of MJO for the period 1974–2015. Four case studies were selected based on a combination of weak and strong monsoons associated with MJO in the active and suppression phases. Results show that in severe monsoons, atmospheric instability increases compared to weak monsoons. Considering MJO and its effect on the monsoon, it is found that the Indian region being in the active phase of MJO is associated with more severe atmospheric instabilities than when MJO is in the suppression phase. While MJO is accompanied by a strong monsoon, it intensifies atmospheric instability.