De In the context of global warming and climate change, carbon dioxide (CO2) is one of the most important greenhouse gases that has significant effects on global warming. (CO2) simulation at hourly/weekly time intervals and good vertical resolution is challenging due to the coarse horizontal resolution of global models. In order to better understand the contribution of different sources of carbon dioxide, the WRF-GHG regional model has been used to simulate atmospheric CO2 over the Middle East region as the first domain and Iran as the second domain. The simulation results in the warm (August) and cold (February) seasons have been compared with the output results of the TM3 global model, against the observational data of the Ghost satellite. From the comparison of the simulated fields of meteorological and chemical variables, it can be seen that the WRF-GHG model performs better than the TM3 global model in terms of statistical errors. The skewness error values of the WRF-GHG model are -0.79 and 0.45 PPMV, respectively.