Deepwater activities such as drilling and production have been ongoing for nearly 50 years, making great contributions to industrialization. Given the increasing demand for energy, along with the restructuring of the energy supply catalyzed by efforts to achieve a low-carbon economy, deep seabed reservoir will play an important role in addressing energy- and resource-related problems in the future. A geohazard assessment workflow is presented that maximizes the use of 3D seismic reflection data to enhance the safety and success of offshore scientific & logical drilling. However, deep seabed mining remains in the exploratory stage, with many challenges presented by the high-pressure, low temperature, and complex geologic and hydrodynamic environments in deep-sea hydrocarbon structures. The importance of integrated geophysical studies for defining investigation scopes is highlighted. The use of the data for the design of surface and subsea development structure foundations and exploration and production wells is reviewed. Finally, this paper gives some key conclusions and future perspectives to provide Geophysics and Geotechnical studies and deep-water operations.