Most of the areas of the Iranian plateau are high seismicity regions and there is a considerable difference between them. These differences in the eastern Iranian plateau including the Lut block concerning the surrounding areas are so substantial, that can be studied independently. In this research, the seismic parameters of the eastern part of Iran, including the Lut block, have been estimated. The most up-to-date catalog of earthquakes has been used and the data has been divided into a historical part and 4 instrumental parts. For each instrumental part, the threshold of data completeness has been determined. The seismic parameters of the region have been estimated taking into account the uncertainty of the magnitudes. Substantially, the estimated b-value is equal to 1.06 and the mean annual occurrence rate for magnitude > 3.1 is 58, which indicates the high seismicity of the region. Finally, the probability of annual exceedance for different magnitudes is estimated for the return periods of 50, 475, and 2475 years.