Doroud Fault, an active and strike-slip fault, is elongated in Doroud-Borujerd plain, NW-SE, as a segment of the main Zagros thrust.The movement of Doroud Fault in March 2006, has caused an Mw 6 Earthquake. In order to study the regional hydrogeology, quantitative and qualitative information of the observation wells of Doroud - Boroujerd plain has been used.The annual hydrographs of the observation wells of Doroud – Brojerd plain, show a sudden increase of three to five meters in some of the wells (wells located near the fault), simultaneous to the earthquake. These sudden increases in water levels indicate the direct effect of earthquake on groundwater table.