Reservoir fluid discrimination is one of the important approaches in the quantitative seismic interpretation, and the evaluation of this approach can be helpful in the development of exploratory studies of hydrocarbon resources. Reducing the drilling risk is one of the most important results of rock physics studies, and the evaluation results of this approach can be efficient in subsurface studies. The main goal of this study is to improve the understanding of seismic response for lithology interpretation and fluid prediction with rock physics modeling and quantitative seismic interpretation in one of the reservoirs in southwest Iran. The results of this study showed that the results of fluid replacement could be improved by integrating the AVO attributes AVO attributes and the cross-plot of different AVO attributes showed that these results could be very efficient in subsurface studies and seismic data interpretation.